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Theme 1. Metal-associated pathomechanisms in Alzheimer's disease

Principal Investigator: Christelle Hureau

We study the coordination of d- (mainly Cu(I/II) and Zn(II)) and f-elements  with the amyloid-β (Aβ) peptide involved in Alzheimer’s disease (AD) and how this could contribute to the origin of the pathology.

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Two main processes are under focus: (i) the Cu-induced production of Reactive Oxygen Species and its intricate mechanism and (ii) the metal-modulated self-assembly of Aβ. A possible synergetic link between the two processes is also under investigation.

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More recently, we are also interested in deciphering at the molecular level the epidemiological link between AD and type-2 diabetes via the study of co-assembly processes.

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