2024

Next-generation Cu(II) selective peptide shuttles prevent Cu(Aβ)-induced toxicity and microglial activation in organotypic hippocampal slices

M. Okafor, D. Schmitt, S. Gasman, L. Raibaut, C. Hureau*, P. Faller*, N. Vitale*, BioRxiv, 2024

Bioinorganic Chemistry of Copper: From Biochemistry to Pharmacology

A.M. Da Costa Ferreira, C. Hureau, G. Facchin, Inorganics 2024

Restoring cellular copper homeostasis in Alzheimer disease: a novel peptide shuttle is internalized by an ATP-dependent endocytosis pathway involving Rab5- and Rab14-endosomes

M. Okafor, O. Champomier, L. Raibaut, S. Ozkan, N. El Kholti, S. Ory, S. Chasserot-Golaz, S. Gasman, C. Hureau, P. Faller* N. Vitale*, Front. Mol. Biosci., 2024

Rationally designed Cu(I) ligand to prevent CuAb-generated ROS production in the Alzheimer's Disease context

C. Rulmont, J.-L. Stigliani, C. Hureau, C. Esmieu*, Inorg. Chem. 2024

Redox processes in Cu-binding proteins: the “in-between” states in intrinsically disordered peptides

E. Falcone, C. Hureau, Chem. Soc. Rev. 2023

Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(Ab) species: a structure-activity relationship

M. Lefèvre, L. Lantigner, L. Andolfo, C. Vanucci-Bacqué, E. Benoist, C. Esmieu, F. Bedos-Belval, C. Hureau, Comptes Rendus Chimie 2023

Synthesis, Characterization, and Biological Properties of the Copper(II) Complexes with Novel Ligand: N-[4-({2-[1-(pyridin-2-yl)ethylidene]hydrazinecarbothioyl}amino)phenyl]acetamide

R. Rusnac, O. Garbuz, Y. Chumakov, V. Tsapkov, C. Hureau, D. Istrati, A. Gulea, Inorganics 2023

Effect of Metal Environment and Immobilization on the catalytic activity of a Cu Superoxide Dismutase Mimic

M. Richezzi, J. Ferreyra, S. Signorella, G. Terrestre, N. Pellegri, C. Hureau, S. R. Signorella, Inorganics 2023

The Critical Role of Ligand Flexibility on the Activity of Free and Immobilized Mn Superoxide Dismutase Mimics

M. Richezzi, S. Signorella, C. Palopoli, N. Pellegri, C. Hureau, S. R. Signorella, Inorganics 2023

LPMO-like activity of bioinspired copper complexes: from model substrate to extended polysaccharides

R. Leblay, R. Delgadillo-Ruiz, C. Decroos, C. Hureau, M. Réglier, I. Castillo Pérez, B. Faure, A. J. Simaan, Chem. Cat. Chem. 2023

Biomimetic catalysis of nitrite reductase enzyme using copper complexes in chemical and electrochemical reduction of nitrite

M. Ferreira, C. Castro, J. Honorato, S. He, W. G. Guimaraes Junior, C. Esmieu, E. Castellano, A. de Moura, D. Truzzi, O. Nascimento, A. Simonneau, C. Marques Netto, Dalton Trans. 2023

Oxidative Damages on the Alzheimer's related-Ab peptide alters its ability to assemble

C. Cheignon, F. Collin, L. Sabater, C. Hureau, Antioxidants 2023

Interfacial behaviour of oligodeoxynucleotides prone to G-quadruplex formation on negatively charged electrode surface monitored by electrochemical probes

D. Dobrovodsky, A. Danhel, E. Mothes-Martin, G. Pratviel, D. Renciuk, J.-L. Mergny, M. Fojta, Electrochimica Acta 2023

Ability of Azathiacyclen Ligands to Stop Cu(Aβ)-Induced Production of Reactive Oxygen Species: [3N1S] is the Right Donor Set

K. P. Malikidogo, M. Drommi, E. Atrián-Blasco, J. Hormann, N. Kulak, C. Esmieu, C. Hureau, Chem. Eur. J. 2023

Can the level of copper in the hippocampus witness type-II diabetes versus Alzheimer's disease?

C. Hureau, eBioMedicine 2023

Sensitization Pathways in NIR-Emitting Yb(III) Complexes Bearing 0, +1, +2, or +3 Charges

E. Mathieu, S. R. Kiraev, D. Kovacs, J. A. L. Wells, M. Tomar, A. Julien, K.E. Borbas, J. Am. Chem. Soc. 2022

Improved emission of Yb(iii) ions in triazacyclononane-based macrocyclic ligands compared to cyclen-based ones

S. R. Kiraev, E. Mathieu, D. Kovacs, J. A. L. Wells, M. Tomar, A. Julien, K.E. Borbas, Dalton Trans. 2022

Synthesis, Structure, and Biologic Activity of Some Copper, Nickel, Cobalt, and Zinc Complexes with 2-Formylpyridine N4-Allylthiosemicarbazone

V. Graur, Y. Chumakov, O. Garbuz, C. Hureau, V. Tsapkov, and A. Gulea, Bioinorganic Chemistry and Applications 2022

Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection

S. Amrane, C. Jaubert, A. Bedrat, T. Rundstadler, P. Recordon-Pinson, C. Aknin, A. Guédin, A. De Rache, L. Bartolucci, I. Diene, F. Lemoine, O. Gascuel, G. Pratviel, J.-L. Mergny, M.-L. Andreola, Nucleic Acids Res. 2022

Synthesis, characterization and superoxide dismutase activity of a biomimetic Mn(III) complex covalently anchored to mesoporous silica

M. Richezzi, C. Palopoli, C. Hureau, S. R. Signorella, J. Inorg. Biochem. 2022

Development of Cu(ii)-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells

M. Okafor, P. Gonzalez, P. Ronot, I. E. Masoudi, A. Boos, S. Ory, S. Chasserot-Golaz, S. Gasman, L. Raibaut, C. Hureau, N. Vitale, P. Faller, Chem.Sci. 2022

Sequence–Activity Relationship of ATCUN Peptides in the Context of Alzheimer’s Disease

M. Lefèvre, K. P. Malikidogo, C. Esmieu, C. Hureau, Molecules 2022

Why the Ala-His-His Peptide Is an Appropriate Scaffold to Remove and Redox Silence Copper Ions from the Alzheimer’s-Related Aβ Peptide

P. Gonzales, L. Sabater, E. Mathieu, P. Faller, C. Hureau, Biomolecules. 2022

Versatile Activity of a Copper(II) Complex Bearing a N4-Tetradentate Schiff Base Ligand with Reduced Oxygen Species

M. Richezzi, J. Ferreyra, J. Puzzolo, L. Milesi, C. M. Palopoli, D. M. Moreno, C. Hureau, S. R. Signorella, Eur. J. Inorg. Chem. 2022

Keggin-type polyoxometalates as Cu(II) chelators in the context of Alzheimer's disease

E. Atrián-Blasco, L. de Cremoux, X. Lin, R. Mitchell-Heggs, L. Sabater, S. Blanchard, C. Hureau, Chem. Commun. 2022

Role of Metal Ions in Alzheimer's Disease:
Mechanistic Aspects Contributing to Neurotoxicity

C. Hureau, in Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities; Govindaraju, T., Ed.; The Royal Society of Chemistry, 2022

Hybrid Bis-Histidine Phenanthroline-Based Ligands to Lessen Aβ-Bound Cu ROS Production: An Illustration of Cu(I) Significance

M. Drommi, C. Rulmont, C. Esmieu, C. Hureau, Molecules, 2021, 26, 7630

A Water-Soluble Peptoid Chelator that Can Remove Cu2+ from Amyloid-β Peptides and Stop the Formation of Reactive Oxygen Species Associated with Alzheimer's Disease

A. E. Behar, L. Sabater, M. Baskin, C. Hureau, G. Maayan Angew. Chem. Int. Ed., 2021, early view

Synthesis, characterization, and biological activity of novel 3d metal coordination compounds with 2-acetylpyridine N4-allyl-S-methylisothiosemi-carbazone

V. Graur, I. Usataia, P. Bourosh, V. Kravtsov, O. Garbuz, C. Hureau, A. Gulea, Applied Organomet. Chem., 2021, 35, e6172

Copper Imbalance in Alzheimer’s Disease and Its Link with the Amyloid Hypothesis: Towards a Combined Clinical, Chemical, and Genetic Etiology

R. Squitti,P. Faller, C. Hureau, A. Granzotto, A. R. White, K. P. Kepp, J. Alzheimer's Dis., 2021, 83 (1), 23-41

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Impact of N-Truncated Aβ Peptides on Cu- and Cu(Aβ)-Generated ROS: CuI Matters!

C. Esmieu, G. Ferrand, V. Borghesani, C. Hureau, Chem. Eur. J., 2021, 27 (5), 1777-1786

Solid-State and Solution Characterizations of
[(TMPA)Cu(II)(SO3)] and
[(TMPA)Cu(II)(S2O3)] Complexes:
Application to Sulfite and Thiosulfate Fast Detection.

L. Berthonnaud, C. Esmieu, S. Mallet-Ladeira, C. Hureau, J. Inorg. Biochem., 2021, 225, 111601

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The aggregation pattern of Aβ1–40 is altered by the presence of N-truncated Aβ4–40 and/or CuII in a similar way through ionic interactions.

E. Stefaniak, E. Atrian-Blasco, W. Goch, L. Sabater, C. Hureau, W. Bal Chem. - Eur. J., 2021, 27 (8) 2798-2809

Reproducibility Problems of Amyloid-β Self-Assembly and How to Deal With Them.

P. Faller, C. Hureau, Front. Chem., 2021, 8, 611227

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Concentration-dependent interactions of amphiphilic PiB- derivative metal complexes with amyloid peptides Aβ and amylin.

S. Majdoub, Z. Garda, A. C. Oliveira, I. Relich, A. Pallier, S. Lacerda, C. Hureau, C. F. G. C. Geraldes, J.-F. Morfin, É. Tóth Chem. - Eur. J., 2021, 27: 2009 –2020

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Unexpected trends in copper removal from Aβ peptide: when less ligand is better and Zn helps.

Esmieu, C., Balderrama-Martínez-Sotomayor, R., Conte-Daban, A., Iranzo, O., & Hureau, C. (2021). Inorg. Chem., 60(2), 1248–1256.

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Measurement of Interpeptidic CuII Exchange Rate Constants of CuII-Amyloid-β Complexes to Small Peptide Motifs by Tryptophan Fluorescence Quenching

Cheryle N. Beuning, Luca J. Zocchi, Kyangwi P. Malikidogo, Charlène Esmieu, Pierre Dorlet, Debbie C. Crans, and Christelle Hureau, Inorg. Chem. 2021, 60, 11, 7650–7659

Electrochemical, spectroscopic, and
computational investigation of a series of polypyridyl ruthenium(II) complexes:
Characterization of reduced states.

Queyriaux, N., Esmieu, C., Gupta, A. K., Vendier, L., Ott, S., Orio, M., & Hammarström, L. (2021).Eur. J. Inorg. Chem., 2021(13), 1263–1270.

SARS-CoV-2 Nsp3 unique domain SUD interacts with
guanine quadruplexes and G4-ligands inhibit this
interaction

M. Lavigne, O. Helynck, P. Rigolet, R. Boudria-Souilah, M. Nowakowski, B. Baron, S. Brülé, S. Hoos, B. Raynal,
L. Guittat, C. Beauvineau, S. Petres, A. Granzhan, J. Guillon, G. Pratviel, M.-P. Teulade-Fichou, P. England, J.-L. Mergny, H. Munier-Lehmann, Nucleic Acids Res., 2021, 49, 13, 7695–7712.

Publications 2015-2020

You will find below the bibliography of our articles published before 2021.