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2024

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A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal stress

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When Metal Complexes Evolve, and a Minor Species is the Most Active: the Case of Bis(Phenanthroline)Copper in the Catalysis of Glutathione Oxidation and Hydroxyl Radical Generation

E. Falcone+, V. Vigna+, H. Schueffl, F. Stellato, B. Vileno,
M. Bouraguba, G. Mazzone, O.  Proux, S. Morante, P. Heffeter,
E. Sicilia+,* and P. Faller*, Angew. Chem.int., 2024

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Next-generation Cu(II) selective peptide shuttles prevent Cu(Aβ)-induced toxicity and microglial activation in organotypic hippocampal slices

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Bioinorganic Chemistry of Copper: From Biochemistry to Pharmacology

A.M. Da Costa Ferreira, C. Hureau, G. Facchin, Inorganics 2024

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Restoring cellular copper homeostasis in Alzheimer disease: a novel peptide shuttle is internalized by an ATP-dependent endocytosis pathway involving Rab5- and Rab14-endosomes

M. Okafor, O. Champomier, L. Raibaut, S. Ozkan, N. El Kholti, S. Ory, S. Chasserot-Golaz, S. Gasman, C. Hureau, P. Faller* N. Vitale*, Front. Mol. Biosci., 2024

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Rationally designed Cu(I) ligand to prevent CuAb-generated ROS production in the Alzheimer's Disease context

C. Rulmont, J.-L. Stigliani, C. Hureau, C. Esmieu*, Inorg. Chem. 2024

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Next-generation Cu(II) selective peptide shuttles prevent Cu(Aβ)-induced toxicity and microglial activation in organotypic hippocampal slices

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Bioinorganic Chemistry of Copper: From Biochemistry to Pharmacology

A.M. Da Costa Ferreira, C. Hureau, G. Facchin, Inorganics 2024

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Restoring cellular copper homeostasis in Alzheimer disease: a novel peptide shuttle is internalized by an ATP-dependent endocytosis pathway involving Rab5- and Rab14-endosomes

M. Okafor, O. Champomier, L. Raibaut, S. Ozkan, N. El Kholti, S. Ory, S. Chasserot-Golaz, S. Gasman, C. Hureau, P. Faller* N. Vitale*, Front. Mol. Biosci., 2024

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Rationally designed Cu(I) ligand to prevent CuAb-generated ROS production in the Alzheimer's Disease context

C. Rulmont, J.-L. Stigliani, C. Hureau, C. Esmieu*, Inorg. Chem. 2024

2023

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Redox processes in Cu-binding proteins: the “in-between” states in intrinsically disordered peptides

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Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(Ab) species: a structure-activity relationship

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Synthesis, Characterization, and Biological Properties of the Copper(II) Complexes with Novel Ligand: N-[4-({2-[1-(pyridin-2-yl)ethylidene]hydrazinecarbothioyl}amino)phenyl]acetamide

R. Rusnac, O. Garbuz, Y. Chumakov, V. Tsapkov, C. Hureau, D. Istrati, A. Gulea, Inorganics 2023

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Effect of Metal Environment and Immobilization on the catalytic activity of a Cu Superoxide Dismutase Mimic

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The Critical Role of Ligand Flexibility on the Activity of Free and Immobilized Mn Superoxide Dismutase Mimics

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LPMO-like activity of bioinspired copper complexes: from model substrate to extended polysaccharides

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Biomimetic catalysis of nitrite reductase enzyme using copper complexes in chemical and electrochemical reduction of nitrite

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Oxidative Damages on the Alzheimer's related-Ab peptide alters its ability to assemble

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Interfacial behaviour of oligodeoxynucleotides prone to G-quadruplex formation on negatively charged electrode surface monitored by electrochemical probes

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Ability of Azathiacyclen Ligands to Stop Cu(Aβ)-Induced Production of Reactive Oxygen Species: [3N1S] is the Right Donor Set

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​Can the level of copper in the hippocampus witness type-II diabetes versus Alzheimer's disease?

C. Hureau, eBioMedicine 2023

2022

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Sensitization Pathways in NIR-Emitting Yb(III) Complexes Bearing 0, +1, +2, or +3 Charges

E. Mathieu, S. R. Kiraev, D. Kovacs, J. A. L. Wells, M. Tomar, A. Julien, K.E. Borbas, J. Am. Chem. Soc. 2022

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Improved emission of Yb(iii) ions in triazacyclononane-based macrocyclic ligands compared to cyclen-based ones

S. R. Kiraev, E. Mathieu, D. Kovacs, J. A. L. Wells, M. Tomar, A. Julien, K.E. Borbas, Dalton Trans. 2022

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Synthesis, Structure, and Biologic Activity of Some Copper, Nickel, Cobalt, and Zinc Complexes with 2-Formylpyridine N4-Allylthiosemicarbazone

V. Graur, Y. Chumakov, O. Garbuz, C. Hureau, V. Tsapkov, and A. Gulea, Bioinorganic Chemistry and Applications 2022

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Synthesis, characterization and superoxide dismutase activity of a biomimetic Mn(III) complex covalently anchored to mesoporous silica

M. Richezzi, C. Palopoli, C. Hureau, S. R. Signorella, J. Inorg. Biochem. 2022

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Development of Cu(ii)-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells

M. Okafor, P. Gonzalez, P. Ronot, I. E. Masoudi, A. Boos, S. Ory, S. Chasserot-Golaz, S. Gasman, L. Raibaut, C. Hureau, N. Vitale, P. Faller, Chem.Sci. 2022

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Sequence–Activity Relationship of ATCUN Peptides in the Context of Alzheimer’s Disease

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Why the Ala-His-His Peptide Is an Appropriate Scaffold to Remove and Redox Silence Copper Ions from the Alzheimer’s-Related Aβ Peptide

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Versatile Activity of a Copper(II) Complex Bearing a N4-Tetradentate Schiff Base Ligand with Reduced Oxygen Species

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Keggin-type polyoxometalates as Cu(II) chelators in the context of Alzheimer's disease

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Role of Metal Ions in Alzheimer's Disease:
Mechanistic Aspects Contributing to Neurotoxicity

C. Hureau, in Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities; Govindaraju, T., Ed.; The Royal Society of Chemistry, 2022

2021

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Hybrid Bis-Histidine Phenanthroline-Based Ligands to Lessen Aβ-Bound Cu ROS Production: An Illustration of Cu(I) Significance

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A Water-Soluble Peptoid Chelator that Can Remove Cu2+ from Amyloid-β Peptides and Stop the Formation of Reactive Oxygen Species Associated with Alzheimer's Disease

A. E. Behar, L. Sabater, M. Baskin, C. Hureau, G. Maayan Angew. Chem. Int. Ed., 2021, early view

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Synthesis, characterization, and biological activity of novel 3d metal coordination compounds with 2-acetylpyridine N4-allyl-S-methylisothiosemi-carbazone

V. Graur, I. Usataia, P. Bourosh, V. Kravtsov, O. Garbuz, C. Hureau, A. Gulea, Applied Organomet. Chem., 2021, 35, e6172

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Copper Imbalance in Alzheimer’s Disease and Its Link with the Amyloid Hypothesis: Towards a Combined Clinical, Chemical, and Genetic Etiology

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Impact of N-Truncated Aβ Peptides on Cu- and Cu(Aβ)-Generated ROS: CuI Matters!

C. Esmieu, G. Ferrand, V. Borghesani, C. Hureau, Chem. Eur. J., 2021, 27 (5), 1777-1786

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Solid-State and Solution Characterizations of
[(TMPA)Cu(II)(SO3)] and
[(TMPA)Cu(II)(S2O3)] Complexes:
Application to Sulfite and Thiosulfate Fast Detection.

L. Berthonnaud, C. Esmieu, S. Mallet-Ladeira, C. Hureau, J. Inorg. Biochem., 2021, 225, 111601

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The aggregation pattern of Aβ1–40 is altered by the presence of N-truncated Aβ4–40 and/or CuII in a similar way through ionic interactions.

E. Stefaniak, E. Atrian-Blasco, W. Goch, L. Sabater, C. Hureau, W. Bal Chem. - Eur. J., 2021, 27 (8) 2798-2809

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Reproducibility Problems of Amyloid-β Self-Assembly and How to Deal With Them.

P. Faller, C. Hureau, Front. Chem., 2021, 8, 611227

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Concentration-dependent interactions of amphiphilic PiB- derivative metal complexes with amyloid peptides Aβ and amylin.

S. Majdoub, Z. Garda, A. C. Oliveira, I. Relich, A. Pallier, S. Lacerda, C. Hureau, C. F. G. C. Geraldes, J.-F. Morfin, É. Tóth Chem. - Eur. J., 2021, 27: 2009 –2020

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Unexpected trends in copper removal from Aβ peptide: when less ligand is better and Zn helps.

Esmieu, C., Balderrama-Martínez-Sotomayor, R., Conte-Daban, A., Iranzo, O., & Hureau, C. (2021). Inorg. Chem., 60(2), 1248–1256.

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Measurement of Interpeptidic CuII Exchange Rate Constants of CuII-Amyloid-β Complexes to Small Peptide Motifs by Tryptophan Fluorescence Quenching

Cheryle N. Beuning, Luca J. Zocchi, Kyangwi P. Malikidogo, Charlène Esmieu, Pierre Dorlet, Debbie C. Crans, and Christelle Hureau, Inorg. Chem. 2021, 60, 11, 7650–7659

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Electrochemical, spectroscopic, and
computational investigation of a series of polypyridyl ruthenium(II) complexes:
Characterization of reduced states.

Queyriaux, N., Esmieu, C., Gupta, A. K., Vendier, L., Ott, S., Orio, M., & Hammarström, L. (2021).Eur. J. Inorg. Chem., 2021(13), 1263–1270.

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SARS-CoV-2 Nsp3 unique domain SUD interacts with
guanine quadruplexes and G4-ligands inhibit this
interaction

M. Lavigne, O. Helynck, P. Rigolet, R. Boudria-Souilah, M. Nowakowski, B. Baron, S. Brülé, S. Hoos, B. Raynal,
L. Guittat, C. Beauvineau, S. Petres, A. Granzhan, J. Guillon, G. Pratviel, M.-P. Teulade-Fichou, P. England, J.-L. Mergny, H. Munier-Lehmann, Nucleic Acids Res., 2021, 49, 13, 7695–7712.

Publications 2015-2020

You will find below the bibliography of our articles published before 2021.

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