Lucie DE CREMOUX
Docteure en analyses physico-chimiques et biochimiques
EDUCATION
2022 - 2025 : PhD in Chemistry-Biology-Health, LCC, Toulouse
Supervisor: Dr Christelle Hureau
2017 - 2018 : Master 2 of Organic Chemistry and Life Sciences, University of Bordeaux, Talence
Organic chemistry, chemical biology, medicinal chemistry, pharmacology.
2016 - 2017 : Master 1 of Organic Chemistry and Life Sciences,University of Bordeaux, Talence
Organic chemistry, Chemical biology, Medicinal chemistry, Pharmacology, Medical imaging techniques.
2015 - 2016 : Licence 3 of Chemistry, University of Bordeaux, Talence
Organic, inorganic and analytical chemistry
2014 - 2015 : DUT in synthetic and analytical chemistry, University of Paris-Sud, Orsay
General, analytical, organic and inorganic chemistry, chemical engineering
INTERNSHIPS
PROFESSIONAL EXPERIENCE
PUBLICATIONS
February 2018 - June 2018
Measuring the one carbon metabolism: validation of a method to simultaneously measure multiple molecules related to one carbon metabolism, Chalmers Mass Spectrometry Infrastructure, Göteborg, Sweden, Sample preparation from plasma or blood, characterization and method validation by mass spectrometry (LC-MS, LC-MSMS, GC-MS)
January 2017 - February 2017
Alzheimer's disease: synthesis of a model peptide of the Tau protein, Institute of Molecular Sciences, Bordeaux
Organic and peptide synthesis, Purification by HPLC, Characterization by Mass Spectrometry
April 2016 - July 2016
Development of novel fluorogenic chemical reporter for the imaging of biomolecules, Aquitaine Institute of Cognitive and Integrative Neurosciences, Bordeaux - Organic synthesis, characterization of molecules by proton, carbon, silicon and fluorine NMR, and mass
May 2015 - July 2015
Development of new chemical probes for glycome imaging, Aquitaine Institute of Cognitive and Integrative Neuroscience, Bordeaux - Organic synthesis, NMR, IR and mass characterization of molecules, fluorescence measurements
2022 - 2025 : PhD in Chemistry-Biology-Health, LCC, Toulouse
Subject: Study of amyloid-β peptide self-assembly by polyanions, under the supervision of Dr Christelle Hureau.
Technical skills: Fluorescence kinetics, FPLC, TEM, UV-Visible spectroscopy, NMR, EPR, IR, Design of analysis protocols.
Cross-disciplinary skills: Communication, writing scientific publications, participating in the organisation of conferences and scientific events, assisting in the organisation of the Science Festival, interdisciplinary collaborations
Training: Supervising research work, training and mentoring new employees (interns and collaborators)
Others: First-level maintenance of equipment (operation and contact with maintenance services)
Representative of non-permanent staff
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June 2019 - August 2021
Study engineer in physicochemical and biochemical analyses at the LCC (CNRS), Toulouse.
Study of β-amyloid peptide aggregation kinetics by fluorescence in the context of Alzheimer's disease research.
Aggregation: preparation of plaques, purification of Aβ peptides by FPLC, kinetics by fluorescence, titration by UV-Visible, visualization of fibers by TEM, data processing
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January 2019 - May 2019
Laboratory technician at Agrobio, Rennes. - Sample preparation, Analyses by UV-Visible spectroscopy, Analyses by liquid chromatography (HPLC)
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L.deCremoux, E.Falcone, D.Schmitt, E.Stefaniak, M.D.WiÅ›niewska, N.Vitale, W.Bal, C.Hureau, Modulation of Aβ1-40 and Aβ4-40 co-assembly by Zinc: getting closer to the biological reality, Inorg.Chem.Front.,2025,12,7827-7844
DOI: https://doi.org/10.1039/D5QI00850F
E.Atrián-Blasco, L.deCremoux, X.Lin, R.Mitchell-Heggs, L.Sabater, S.Blanchard, C.Hureau, Keggin-type polyoxometalates as Cu(II) chelators in the context of Alzheimer's disease,Chem.Commun.,2022,58,2367-2370
DOI: https://doi.org/10.1039/D1CC05792H
C.Favre, L.deCremoux, J.Badaut, F.Friscourt, Sydnone Reporters for Highly Fluorogenic Copper-Free Clic Ligations,J.Org.Chem.,2018,83,2058-2066
Project
Participation to the ERC (European Council Research) project: “AlzINK, Alzheimer’s disease & Zinc : The missing link ?” leaded by Christelle Hureau.