Emilie MATHIEU
Associate researcher
Research
My principal project focuses on developing artificial lanthanide enzymes as models of lanthanide methanol dehydrogenases. We aim to deepen our understanding of the interactions between lanthanide ions and peptides, as well as the role played by the metal ion in the catalytic activity of the enzyme.
I am also involved in two side projects: (i) the investigation of the ability of Ln-complexes to modulate the amyloid-β assembly process, and the characterization of the interactions responsible for it; (ii) the development of bio-inspired copper catalysts
CV
EXPERIENCES
EDUCATION
Since 10/2021
09/2020 - 07/2021
05/2018 - 05/2020
09/2017 - 03/2018
2014 - 2017
2016
2013 - 2014
Associate researcher at LCC-CNRS (UPR8241), Toulouse, France - Team ALAMBIC
Keywords: enzyme mimics, Ln(III), luminescence
Post-doc at LCC-CNRS (UPR8241), Toulouse, France - Christelle Hureau group
Keywords: catalysis, Cu(II), amyloids, Michael addition, C-C bond formation
Post-doc at Uppsala University, Uppsala, Sweden - Group of Prof. Eszter Borbas
Keywords: photo-induced electron transfer, Ln(III) complexes, spectroscopy, electrochemistry
Postdoc at Ecole Normale Supérieure, Paris, France - Group of Prof. Clotilde Policar
Keywords: X-ray fluorescence imaging, subcellular distribution, Mn(II) complex
PhD in Bioinorganic Chemistry at Sorbonne University, Paris, France
Supervisor: Prof. Clotilde Policar and Dr. Nicolas Delsuc
Keywords: superoxide dismutase mimics, Mn(II), oxidative stress, inflammation, bioavailability
Visiting PhD student (3 months) at Michigan University, Ann Arbor, USA
Group of Prof. Vincent Pecoraro
Keywords: superoxide dismutase mimes, coiled coils, rational enzyme design, Cu(II)
Pre-doctoral internship
Simon Fraser University, Vancouver, Canada
Group of Prof. Tim Storr
Keywords: organic synthesis, Cu(II) complexes, oxidative stress, amyloid, Alzheimer's disease
ORGANISATION OF MEETINGS
FUNDINGS
PUBLICATIONS
2024
2023-2027
Chair of the 2nd MBP (Metal-Binding Peptides) international conference with C. Hureau
Toulouse, France, July 10-12, 2024
LNZYME - Lanthano-peptides as mimics of lanthanide methanol dehydrogenase enzyme
ANR (French National Research Agency)
You will find all my publications with the following link: https://orcid.org/0000-0002-9313-8679
Selected research articles
Sensitization pathways in NIR-emitting Yb(III) complexes bearing 0, +1, +2, or +3 charges, E. Mathieu†, S. R. Kiraev†, D. Kovacs, J. A. Wells, M. Tomar, J. Andres, K. E. Borbas*
J. Am. Chem. Soc. 2022, 144, 21056-21067
Coordination environment-controlled photoinduced electron transfer quenching in luminescent europium complexes, D. Kovacs†, E. Mathieu†, S. R. Kiraev†, J. A. L. Wells, E. Demeyere, A. Sipos, K. E. Borbas*
J. Am. Chem. Soc. 2020, 142, 13190-13200
Rational De Novo Design of a Cu-Metalloenzyme for Superoxide Dismutation, E. Mathieu†, A. E. Tolbert†, K. J. Koebke, C. Tard, O. Iranzo, J. E. Penner-Hahn, C. Policar, V. Pecoraro*
Chem. Eur. J. 2020, 26, 249-258
Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese (II) superoxide dismutase mimic complex, E. Mathieu, A. S. Bernard, E. Quévrain, M. Zoumpoulaki, S. Iriart, C. Lung-Soong, B. Lai, K. Medjoubi, L. Henry, S. Nagarajan, F. Poyer, A. Scheitler, I. Ivanovic-Burmazovic, S. Marco, A. Somogyi, P. Seksik, N. Delsuc, C. Policar*
Chem. Commun. 2020, 56, 7885-7888
A cell-penetrant manganese superoxide dismutase (MnSOD) mimic is able to complement MnSOD and exerts an antiinflammatory effect on cellular and animal models of inflammatory bowel diseases, E. Mathieu†, A.-S Bernard†, N. Delsuc, E. Quévrain, G. Gazzah, B. Lai, F. Chain, P. Langella, M. Bachelet, J. Masliah, P. Seksik, C. Policar*
Inorg. Chem. 2017, 56, 2545-2555
Selected review:
Lanthanide-based tools for the investigation of cellular environments, E. Mathieu, A. Sipos, E. Demeyere, D. Phipps, D. Sakaveli, K.E. Borbas*
Chem. Commun. 2018, 54, 10021-10035