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Charlène ESMIEU

Associate researcher

Tel : +33 5 61 33 31 20

charlene.esmieu@lcc-toulouse.fr

Research

My main focus in the team is to develop and synthesize new fluorescent ligands able to prevent the Cu-Aβ-associated toxicity and ultimately rebalance Cu between intra- and extracellular compartments, and to gain fundamental knowledge about key molecular processes in AD context for therapeutic purposes.

CV

EDUCATION

2014      PhD in inorganic and bio-inorganic chemistry

Laboratory of Chemistry and Biology of Metals – UMR 5249 – CEA-CNRS-UGA, Grenoble – France

Supervisors : Dr. Stéphane Ménage and Dr. Stéphane Torelli

Structure-activity relationships in copper complexes bio-inspired from nitrous oxide reductase
2011      Master’s degree: bio-organic & bio-inorganic chemistry 

Joseph Fourier University – Grenoble – France

POSITIONS

Since October 2019
CNRS researcher in the “Alzheimer and amyloids” Group – Coordination Chemistry Laboratory (LCC) – UPR CNRS 8241, Toulouse (headed by Dr. Christelle Hureau)
Syntheses and studies of fluorescent Cu-targeting drugs in Alzheimer disease context


2018 - 2019
Post-doctoral PRESTIGE Fellow and Marie Curie Fellow in the “Alzheimer and amyloids” Group – Coordination Chemistry Laboratory (LCC) – UPR CNRS 8241, Toulouse with Dr. Christelle Hureau
Studies of Cu-chelators and Effect of the N-truncation of Aβ peptides on the ROS production by their copper complexes in the context of Alzheimer disease


2015 - 2018
Post-doctoral Fellow (Wenner-Gren Foundation) in the “bio-physical and bio-inorganic chemistry” Group – Department of Chemistry, Ångström Laboratory – Uppsala University – Sweden with Dr. Gustav Berggren
Design and preparation of artificial hydrogenases - chemistry and biology in synergy

 

AWARDS

2020     ANR funded project: Copperation

2019     Best poster award at JCC2019
2018     PRESTIGE co-financing grant award (Marie Curie FP7)
2016     Travel grant (EuroBIC’13) from the Wenner-Gren Foundation (https://www.swgc.org)
2016     Two-years postdoctoral scholarship from the Wenner-Gren Foundation (https://www.swgc.org)
2015     Poster selected for a flash poster presentation at ISF-1 (International Solar Fuels Conference)
2013     Best poster award at ICBIC’16 (International Conference on Bio-Inorganic Chemistry)
2013     PhD Best Publication Award of the Chemistry-Biology Department, Grenoble University

COMMUNICATIONS

14 oral communications in national and international conferences including 1 Inorganic Reaction Mechanisms & Inorganic Biochemistry Discussion Group Meeting, Manchester, UK, 2019, 1 Young researcher lecture, EuroBIC 13, Budapest, Hungary, 2016, 2 Swedish Consortium for Artificial Photosynthesis, Uppsala University, Sweden, 2016/2017
8 poster presentations in national and international conferences

Publications

Author of 20 articles published in international peer-reviewed journals ; 12 as first author ; 2 Energy Environ. Sci., 2 Angew. Chem. Int. Ed., 2 Chem. Sci., 2 Chem. Eur. J., 1 Sustainable Energy Fuels, 5 Inorg. Chem., 4 Dalton trans., 1 J. Inorg. Biochem., and 1 Eur. J. Inorg. Chem.

  • Esmieu, C., Balderrama-Martínez-Sotomayor, R., Conte-Daban, A., Iranzo, O., & Hureau, C. (2021). Unexpected trends in copper removal from Aβ peptide: when less ligand is better and Zn helps. Inorg. Chem., 60(2), 1248–1256. DOI: https://doi.org/10.1021/acs.inorgchem.0c03407

 

  • Queyriaux, N., Esmieu, C., Gupta, A. K., Vendier, L., Ott, S., Orio, M., & Hammarström, L. (2021). Electrochemical, spectroscopic, and computational investigation of a series of polypyridyl ruthenium(II) complexes: Characterization of reduced states. Eur. J. Inorg. Chem., 2021(13), 1263–1270. DOI: https://doi.org/10.1002/ejic.202001165

 

  • Esmieu, C., Guettas, D., Conte-Daban, A., Sabater, L., Faller, P., & Hureau, C. (2019). Copper-targeting approaches in alzheimer’s disease: how to improve the fallouts obtained from in vitro studies. Inorg. Chem., 58(20), 13509–13527. DOI: 10.1021/acs.inorgchem.9b00995

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